DIVERGENCE OF METABOLITES IN THREE PHYLOGENETICALLY CLOSE MONASCUS SPECIES (M. PILOSUS, M. RUBER, AND M. PURPUREUS) BASED ON SECONDARY METABOLITE BIOSYNTHETIC GENE CLUSTERS

Abstract Background Species of the genus Monascus are considered to be economically important and have been widely used in the production of yellow and red food colorants.In particular, three Monascus species, namely, M.pilosus, M.purpureus, and M.ruber, are used for food fermentation in the cuisine of East Asian countries such as China, Japan, and

MicroRNAs (miRNAs) can regulate tumor cell invasion and metastasis in a tumor-specific manner.We recently demonstrated that global downregulation of miRNAs after deleting dicer can promote development of distant metastases in muumi lyhty a mouse model of primary soft tissue sarcoma (STS).In this study, we identified miRNAs that are differentially d

DNA-functionalized gold nanoparticles (AuNPs) have been widely used in directed assembly of materials, biosensors, and drug delivery.This conjugate may encounter proteins in these applications and proteins may affect not only DNA adsorption but also the function of the attached DNA.Bovine serum albumin (BSA) with many cysteine residues can strongly

Increased expression of androgen receptor (AR) in prostate cancer (PC) is associated with transition to androgen independence.Because the progression of PC to advanced stages is often associated with the loss of p53 function, we tested whether the p53 could regulate the expression of AR gene.Here we report that p53 negatively regulates the expressi